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KMID : 0043320180410020111
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Archives of Pharmacal Research
2018 Volume.41 No. 2 p.111 ~ p.129
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Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications
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Ruttala Hima Bindu
Ramasamy Thiruganesh
Madeshwaran Thiagarajan
Hiep Tran Tuan
Kandasamy Umadevi
Oh Kyung-Taek
Choi Han-Gon
Yong Chul-Soon
Kim Jong-Oh
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Abstract
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The development of novel drug delivery systems based on well-defined polymer therapeutics has led to significant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnology, and nanomedicine have revolutionized the practices of drug delivery. Stimulus-responsive material-based nanosized drug delivery systems have remarkable properties that allow them to circumvent biological barriers and achieve targeted intracellular drug delivery. Specifically, the development of novel nanocarrier-based therapeutics is the need of the hour in managing complex diseases. In this review, we have briefly described the fundamentals of drug targeting to diseased tissues, physiological barriers in the human body, and the mechanisms/modes of drug-loaded carrier systems. To that end, this review serves as a comprehensive overview of the recent developments in stimulus-responsive drug delivery systems, with focus on their potential applications and impact on the future of drug delivery.
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KEYWORD
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Nanomedicine, Polymer therapeutics, Drug delivery systems, Stimulus-responsive
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